Conduction block (CB) is the failure of an action potential (AP) to propagate through an intact axon of a motoneuron. The routinely used methods in clinical practice for CB estimation are based on the comparison of the area and the amplitude of two compound muscle action potentials (CMAPs) elicited with transcutaneous electrical nerve stimulation at sites proximal and distal to the nerve segment in which CB is suspected. The CB estimation obtained with these standard clinical methods is altered by the phase cancellations produced by temporal dispersion of the MUAPs constituting the CMAP. The temporal dispersion is abnormal in subjects with neuropathies that cause important reduction of peripheral nerves conduction velocity by disrupting the myelin sheath (demyelinating diseases).