This study focusses on the emergence, development, and institutionalization of quarantine architecture, aiming to understand how buildings have played a pivotal role in epidemic governance. The selection of this theme stems from contemporary society's renewed exposure of spatial requirements and vulnerabilities during pandemics, as well as the profound differences in how various societies in the past perceived and confronted contagious disease. This thesis first outlines the major epidemic contexts from the 12th to the 19th centuries, examining diachronically how origins and transmission were perceived, and their social and political consequences. It demonstrates that these perceptions directly influenced the emergence of isolation spaces and the evolution of architectural forms.