Drug encapsulation represents one of the most relevant topics in pharmaceutical sciences, particularly through the use of block copolymer materials in the form of spherical micelles. In this context, Pluronics are widely studied thanks to their biocompatibility and thermosensitivity. They are non-ionic amphiphilic copolymers consisting of a hydrophobic central chain of polypropylene oxide (PPO) and two hydrophilic lateral chains of polyethylene oxide (PEO). Due to their amphiphilic nature, Pluronics self-assemble into micellar structures in aqueous solutions above a critical concentration and temperature, known respectively as CMC and CMT. Among these, a particularly interesting system is represented by Pluronic F68 which, in aqueous solution at 45% by weight, exhibits a peculiar thermosensitive transition.