Cancer is among the leading causes of death worldwide. The International Agency for Research on Cancer estimates that in twenty years the rates of incidence and mortality of cancer will have an increase of 63% and 74%, respectively. Currently, the main types of cancer treatments are surgical intervention, chemotherapy, radiotherapy and immunotherapy. Each of these therapeutic approaches has advantages and disadvantages, dependent on the specific tumor type, its size, the presence of metastasis and the inter-patient variability. Beyond its genetic basis, it is crucial to recognize cancer also as a metabolic disease. Consequently, a promising antitumoral strategy could be to focus on the lactate dehydrogenase (LDH) enzyme, given its pivotal role in tumor metabolism.