The increase in population, scarcity of fertile lands and urbanization constitute a widespread challenge that is impacting food security worldwide. In response, Controlled Environment Agriculture (CEA) is becoming increasingly popular due to its focus on optimizing agricultural practices, resource management and space use (particularly in Vertical Farming), aiming to identify the most efficient methods for crop cultivation. Within the framework of CEA, soilless agriculture stands out, including techniques such as hydroponics, aeroponics, aquaponics and bioponics. This thesis aims to evaluate whether the AquaCrop model, designed for traditional soil-based agriculture, accurately simulates the growth of lettuce (Lactuca sativa) in an aeroponic system implemented at Politecnico di Torino by comparing the simulated dry biomass with the one measured experimentally.