During the last decades, the tendency of developing smart materials has skyrocketed in a multitude of fields, especially in those where interaction with biological systems is researched, e.g. soft robotics. In this context, supramolecular hydrogels have attracted a great deal of interest because of their ability to respond to diverse external triggers while maintaining elasticity and a soft texture. Even if DNA is well-known for being the most precious molecule within living organisms as it holds the secret of life, it is still a biopolymer and can be included in stimuli-responsive hydrogels. This offers many advantages because H-bonds between base pairs of complementary DNA strands produce a highly specific and reversible response.