Cardiovascular diseases (CVDs) are the leading cause of illness and death worldwide, with heart failure resulting from myocardial infarction being the most fatal among all CVDs. All available approaches for CVD treatment, including medical device implantation, pharmaceutical therapy, and transplants, have significant limitations. In this context, there is a growing demand for advanced and reliable in vitro cardiac tissue models able to provide (i) a deeper understanding of the biophysical and biomolecular pathways of cardiac muscle and CVDs, and (ii) promising new strategies for repairing and regenerating damaged cardiac tissue and discovering potential therapies that could significantly improve patient survival. To address these challenges, traditional Cardiac Tissue Engineering (CTE) approaches are currently translated towards the design of in vitro 3D cardiac models.