Embarking on the adaptive reuse of Palazzo del Lavoro, a distinguished modern movement masterpiece by Pier Luigi Nervi and Gino Covre, this exploration addresses the significant challenge presented by its extended state of abandonment. Following the acquisition by Cassa Depositi e Prestiti, the iconic building stands at the threshold of transformative redevelopment. Envisioning Palazzo del Lavoro as a dynamic startup and innovation hub, the proposal seeks seamless integration of diverse functions, including a shopping center, science museum, university, event space, and coworking area. Navigating the intricate economic landscape played a pivotal role in shaping the core aspects of this thesis. A comprehensive analysis of potential stakeholders and investors served as the guiding compass for the pursuit of an economically viable transformation.