Cardiovascular diseases (CVDs) are the leading cause of death worldwide, taking more than 17 million lives according to the World Health Organization (WHO) and costing approximately €210 billion annually to the European Union. Each disease has its risk factors, and one of the most common denominators is the development of atherosclerosis, which is characterized by the thickening or stiffening of the arteries. Arterial stiffness is due to the loss of the artery walls’ distensibility, causing increased blood pressure and speed with which the pulse wave propagates in the arterial tree. Relative to the latter, the Pulse Wave Velocity (PWV) measurement has demonstrated to be one of the best non-intrusive ways to estimate arterial stiffening.