Sviluppo di un modello 3D in vitro dell’unità acino-duttale pancreatica, attraverso tecnologie di additive manufacturing In the last decade a vast number of pathologies connected to both endocrine and exocrine components of pancreas have been observed to arise with an increasing rate in their occurrence; in particular the pancreatic ductal adenocarcinoma (PDAC) stands out as the main neoplastic disease of the pancreas and as an extremely lethal malignancy with an increasing frequency in the occurrence. PDAC has a low survival rate, which is connected to the late diagnosis due to lack of specific and clear symptoms before late stages and the resistance to current treatments ascribed to the structure and composition of the tumor microenvironment.