Total knee replacements (TKRs) represent the gold standard for treating knee osteoarthritis. Nowadays, a variety of TKR designs are available on the market, differing mainly in geometrical features, degrees of freedom (DoFs) allowed to the implanted knee, and degree of tissue resection in order to adapt to various patient needs. Despite the significant evolution of this type of implant over the last 50 years, especially specific prosthesis designs still exhibit mechanical and structural limitations. Among the hinged total knee prostheses, generally characterized by one or three DoFs, the PANTHEON prosthesis (Adler Ortho SpA) features a particular design allowing for two DoFs.