This study has the aim to detect and analyse the cause and effect relationships in an Industry 5.0 framework, between the digital paradigms of Industry 4.0 (I4.0), enabled by Key Enabling Technologies (KETs) and the targets of three Sustainable Development Goals (SDG), permeated by Lean Manufacturing (LM) and Circular Economy (CE) principles. The SDGs in question belong to the ones linked to the Economical dimension, according to the division of the Stockholm Resilience Centre and they are number 8, “Decent Work and Economic Growth”, number 9 “Industry, Innovation and Infrastructure” and number 12, namely “Responsible Production and Consumption”, that will be called “SME SDGs” from now on.