Unmanned Aerial Systems (UAS) represent a great opportunity for the future of aviation, offering new services and performing existing ones in a more affordable and effective manner. UAS were initially employed for military purposes, but in recent years, they become increasingly popular in the civilian sector. To fully exploit the potential of this market, a regulatory framework is needed not only to guarantee that all unmanned system services are provided in a way that ensure safety, sustainability, privacy, and affordability, but it is also a key issue to attract stakeholders’ interest in this emerging technology and encourage economic investments from the industry.