Computational modeling of the cellular mechanism of Alzheimer's disease initiation due to tau protein hyperphosphorylation.

Alzheimer’s Disease (AD) is the most common form of dementia and one of the most impactful neurodegenerative diseases. Among several hypothesis of what could trigger the disease, the one investigated in this work is the Tau hypothesis. According to this, AD is triggered by an abnormal hyperphosphorylation of the protein tau, causing a detachment of the protein from microtubules (MTs) and consequent loss of stabily, leading so to their disruption and neuronal death. In addition, studies have found a correlation between tau hyperphosphorylation and temperature that can vary the activity of kinases and phosphatases. More in-depth, in this work our objective is to develop and explore a computational model of the cellular mechanism of the disease initiation due to tau protein hyperphosphorylation.