The increasing resistance of bacteria to conventional antibiotics and the limited therapeutic efficacy of current alternative antimicrobial agents have propelled society to a post-antibiotic era. Dental implants have been the focus of extensive investigation in recent years with the fundamental aim of preventing implant failure and antimicrobial resistance. The principal etiologic factor that causes inflammation condition of peri-implant tissues is the oral biofilm in the trans-mucosal region, particularly around the collar and abutment of the implant, which significantly differs from the interface between the gingiva and natural teeth. Antimicrobial peptides (AMPs) have gained attention as possible alternative drugs thanks to their advantages, including the ability to hamper the development of resistance by pathogens and their high selectivity.