The complexity of modern applications poses significant challenges in maintaining system security and trustworthiness. Applications across various domains, ranging from Cloud Computing to the Internet of Things, often rely on processing sensitive data and hence require execution within a secure environment that isolates them from other untrusted applications. As a result, in recent years Trusted Execution Environments (TEEs) have been developed to offer a secure area where data and code can be securely processed and stored, providing strong isolation guarantees. This thesis focuses specifically on Keystone Enclave, an open-source Trusted Execution Environment framework built upon the RISC-V Instruction Set Architecture. Keystone Enclave aims to address by design the limitations observed in other existing TEE technologies.