Fusion power offers the prospect of an almost inexhaustible source of energy for future generations. Although this may be true, it also presents so far insurmountable scientific and engineering challenges. Under these circumstances, today, many countries take part in fusion research to some extent, led by the European Union, the USA, Russia and Japan, with vigorous programs also underway in China, Brazil, Canada, and Korea. Nuclear fusion reactor studies are mostly devoted to the Deuterium-Tritium (DT) fuel cycle. Neutron-induced transmutation of materials in a DT fusion power plant will give rise to the potential for long-term neutron-induced radioactivity in structures. To ensure the attractive safety and environmental characteristics of fusion power, careful design choices are necessary: the reliance on deuterium and tritium as the sole fusion fuels must be reconsidered, given the recent availability of new superconducting materials at high temperature, which could enable to obtain the high magnetic fields necessary for the confinement of Deuterium- Helium3 (DHe3) plasmas.