Abstract Climate change is a critical global phenomenon that is developing in several local environment emergencies in recent years. Thanks to an increased sensibility and concern regarding this subject, we are witnessing the adoption of different strategies and goals for the reduction of emissions and mitigation of environmental impact. The road transport sector is one of the major contributors to greenhouse gas (GHG) emissions, as it is still largely reliant on traditional powertrains solutions. While some progresses have been observed in the passenger car sector, heavy-duty transport remains mainly founded on diesel internal combustion engines. This Master of Science thesis aims to evaluate and compare from economic perspective three possible solutions for the decarbonization of heavy-duty freight transport: • Battery electric trucks • Fuel cell electric trucks • Hydrogen fueled internal combustion engine trucks The analysis is based on the Total Cost of Ownership method, that allows to consider cost elements of the vehicles throughout their entire usage period.