Due to their relevant energy and environmental impact, buildings are recognized among the main causes of climate change. Consequently, buildings must undertake the decarbonization process, which is one of the most decisive solutions to curb, to achieve the sector transition, which will be guided by higher electrification of end-uses and deployment of renewable energy sources. Furthermore, future buildings performance, in terms of energy needs and occupants’ comfort, will inevitably be affected by a wide range of foreseeable and unforeseeable events during the operational phase (e.g., energy supply interruptions, external air temperature increase, natural events, occupants’ habits, etc.). Therefore, the design of new constructions and the retrofit of existing buildings cannot be performed with the sole objective of achieving high energy performances, but it asks for the introduction of features capable of increasing buildings robustness and resilience to deal with a wide range of elements that can impact on their operations and performances.