In the last years, modern computational fluid dynamics started to have a significant role during the design phase and safety reviews of most nuclear systems. The American Society of Mechanical Engineers (ASME) V&V 30 Subcommittee on Verification and Validation in Computational Nuclear System Thermal Fluids Behavior launched a series of challenges in order to test the state of the practice in using and applying computational tools. The purpose of this Master's thesis is to provide an answer to the benchmark problem no.2: "Single-Jet Computational Fluid Dynamics (CFD) Numeric Model Validation". This work, in fact, describes the validation process of multiple RANS and DES setups using the experimental data provided by previous 2D TR-PIV tests.