Colorectal adenocarcinoma (CRAC) is the third most commonly diagnosed form of cancer in the world and the second leading cause of cancer deaths. This type of cancer originates from the epithelial cells of the colorectal mucosa, it usually starts from the inner lining and afterwards spreads to other layers and it is normally characterized by glandular formation. The recommended treatment typically consists of resection if the tumor is at an early-stage and chemotherapy or radiotherapy in case the cancer is at a more advanced stage. However, most therapeutic approaches appear challenging because of the molecular and functional heterogeneity shown by these tumors, making it difficult for clinicians to come up with an adequate treatment plan.