Cell migration is one of the most important and most studied phenomena in biology and plays a fundamental role for many physiological and pathological processes such as morphogenesis, wound healing and tumorigenesis. In the body many cells, such as fibroblasts, migrate individually by adhering to a protein substrate known as the extracellular matrix (ECM). There are many mechanisms affecting cell motion. For instance, it is well known that cells sense the concentration gradients of particular chemicals and migrate attracted or repelled by them (chemotaxis). In recent years, researchers have performed experiments demonstrating that cells can also migrate in response to mechanical stimuli of the substrate to which they adhere: motion toward regions with higher stiffness is called durotaxis, while motion guided by the stress or the deformation of the substrate itself is called tensotaxis.