Cancer is one of the major causes of morbidity and mortality in the world and one possible complication is the spread of metastases in the spine. The presence of vertebral metastases strongly affects the anatomical structure and mechanical properties of the bone and can lead to fracture, pain, disability and impairment of quality of life. Evaluating the mechanical strength of the pathologic vertebrae is thus fundamental in order to provide an objective support to the clinic decision and treatment plan. The current clinical methods used for the diagnosis of vertebral fracture are mainly based on bone mineral density and qualitative assessment of radiological data; however, they do not provide an objective and accurate fracture risk estimation.