During Myocardial infarction (MI), cardiomyocytes (CMs) irreversible death occurs, leading to the formation of a non-contractile fibrotic scar. To date, heart transplantation remains the only effective clinical therapy to restore heart function. An alternative promising strategy is the use of injectable hydrogels as minimally invasive systems for the release of bioactive agents for cardiac repair. In situ release of specific micro-RNAs (miRNAs) has been previously found to trigger direct reprogramming of human cardiac fibroblasts (CFs) into CMs, favoring heart regeneration. Alginate-based injectable hydrogels are widely used in biomedical applications thanks to their promising results in supporting cardiac regeneration. However, alginate (ALG) presents some limitations such as low degradability in vivo and poor cell adhesion.