Analysis and diffusion modelling of a drug delivery system for biomedical applications: Curcumin-loaded PLGA microcarriers, from discrete to continuum domain
Alessandro De Giorgi
Analysis and diffusion modelling of a drug delivery system for biomedical applications: Curcumin-loaded PLGA microcarriers, from discrete to continuum domain.
Rel. Matteo Fasano, Carlo Ricciardi. Politecnico di Torino, Corso di laurea magistrale in Nanotechnologies For Icts (Nanotecnologie Per Le Ict), 2021
Abstract
Nanomedicine systems offers multiple benefits in treating chronic respiratory and tumoral diseases by site-specific, and target-oriented delivery of precise medicines, employing materials in the nanoscale range. In this context, South Korea has become one of the most active countries. In particular, Yonsei university is one of the most research-intensive institute, with a thriving community of innovative and world-leading researchers. Within this scenario, an heterogenous team in the medical research department of Wonju, composed by nanotechnologists, biologists and engineers, is working on micro-sized polymeric PLGA-based discoidal particles as carriers for the transport and delivery of lung-targeted drugs, in order to improve the therapeutic efficiency and safety of such theranostic systems.
The ambitious and innovative work described in this dissertation concerns the simulation of the chemical structure of a drug-loaded PLGA matrix using molecular dynamics simulations with the help of the software Gromacs, in order to obtain a physical diffusion model able to fit the experimental data attained in the laboratory sessions by the research group in Wonju
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