In the background of this new and commercial economy, various projects and mission are turned towards the transportation to Low-Earth Orbit and the management of experiments developed by private entities. To accomplish this demand, also the European Space Agency is working on vehicles and platforms that allow experimentation in a microgravity environment, as well as the in-orbit validation and demonstration of technologies and the satellites inspection. Such systems could have the advantage of being uncrewed and reusable, therefore the chance of returning experiments to Earth is a very important utility. The main objective of this study is to provide guidelines and the first results of a design and development process of a payload accommodation facility to be installed on space systems aimed at the in-orbit experimentation.