Chronic pathologies affect a large part of the adult population and often cause hospitalization, reduced quality of life, and even death. Therefore, treating these pathologies is a critical issue that is further complicated by problems related to traditional drug administration methods and patients adherence. The need to overcome these limits is leading to the development of innovative devices for controlled drug release; however, although research is making great strides, a fully implantable device, that allows for fine control of drug dosage after implantation, is still an unmet clinical need. In this context, nanofluidic membranes are up-and-coming devices. They enable a controlled release without any mechanical component due to their nanometric channels, which allow a concentration-independent drug flow.