The future improvements of medicine require personalized drug therapies, direct consequence of a precise health parameters analysis. In order to achieve a continuous real-time monitoring, the optimal solution is represented by implantable medical devices (IMD), typically composed by a sensor, a battery and a circuital control module. However, the presence of a battery reduces the autonomy of IMDs, requiring periodical maintenance, causing heat dissipation and increasing the total occupation area. Enzymatic biofuel cells (EBFCs) partially solve problems typical of a lithium-ion battery: an EBFC generates electrical power converting chemical energy obtained from the reaction between an enzyme present in the human blood and electrolytes, with a reduced generation of by-products.