Due to different levels of tasks and working conditions, workers in the industrial production process are faced with various unavoidable risks. Unfortunately, the death, injury, and disease caused by work have become too common, and with the emergence of more and more safety problems, it not only seriously damages the physical and mental health of workers but also brings unpredictable economic consequences to production plants. This paper analyzes the safety hazards in the industrial production process and identifies the possible risk factors in the production process according to the definition of the Customized Risk Assessment matrix. After that, based on the technical background of industry 4.0, several possible advanced technologies are proposed to monitor and control these variables in the process of risk assessment, and it is assumed that wireless sensors technology and other technologies are used to collect the data and for subsequent calculation.