The present work focuses its attention on the European project Waste2Watss, which aim to design and construct a large-scale biogas fed SOFC power plant. Biogas is produced from a large farm through anaerobic digestion, consisting mainly in methane and carbon dioxide, with a certain amount of contaminant to be removed. However, to ensure long-term SOFC operations, biogas feeding the cell should be ‘cleaned’ form sulphur compounds, siloxane and mercaptans. Up to now, many commercially available technologies aims to this purpose, even though for pure biomethane production. Therefore, the purpose of the present work is to design a proper biogas cleaning system based on cryogenics, avoiding the usage of chemicals or biological agents.