In the last decades, bone tissue regeneration has been one of the most discussed research topics in the field of regenerative medicine. Bone tissue is able to regenerate itself but, in the presence of extensive bone defects, surgery is required to insert a bone graft that will promote healing. Synthetic bone grafts, also known as scaffolds, are porous 3D structures able to imitate the extracellular matrix (ECM) of natural bone and help natural tissue regeneration. Additive manufacturing (AM) plays an important role in the creation of scaffolds with a highly porous and interconnected architecture. The present experimental work aimed at producing hydroxyapatite (HA) highly-interconnected porous scaffolds able to imitate the trabecular architecture of spongy bone.