The hydrogen produced for fuel cell vehicles must respect the purity requirements described by the ISO standards. Here the case of the hydrogen refueling station located in Karlsruhe is analyzed. The solid oxide electrolysis system installed at the station produces hydrogen on-site with nitrogen and oxygen concentrations higher than the ISO limits. A fine-purification of the product hydrogen is thus required, but all the technologies currently implemented for this purpose are energy-intensive and not suitable for the case. As a consequence, an alternative process for hydrogen purification through nitrogen removal is demanded. The highly porous MOF materials combined with membrane- or column-based technologies are an interesting candidate for gas separation applications, as they are fine-tunable and can be tailored in terms of pore size and distribution.