Small extracellular vesicles (sEVs) of sizes between 30 and 200 nm are released from almost all the cells of the human body in the extracellular space (i.e. outside the cell of origin). By traveling through body fluids (blood, urine, saliva, etc.) these nano-sized vesicles transport biological information between distant cells in the form of lipids, proteins, RNAs and DNAs among others. This novel way of cell-to-cell communication interaction has been discovered to be important in the development of several diseases, such as cancer development and metastasis. Hence, the study of sEVs is crucial for the early non-invasive diagnosis and therapy of different forms of cancer (e.g.