Cancer is considered the leading cause of death and estimates assess that the new tumor cases will rise to 20.3 million per year with 13.2 deaths by 2030. For improving drug delivery, pharmaco-kinetics, bio-distribution and real-time tracking, the past decade research has been focusing into the development of new theranostic systems able to combine a therapeutic compound with an imaging probe in the same vehicle, able to selectively target cancer cells. In this work we developed microcapsules, combining the bioimaging properties of excitation-dependent fluorescent graphene quantum dots (GQDs) with therapeutics-loaded microparticles functionalized by electrostatic Layer by Layer (LbL), using calcium carbonate (CaCO3) core as template.