Road accidents caused by distraction and drowsiness are two of the main causes of mortality on Italian roads. The impact of this category of accidents is maximized when heavy vehicles for the transport of dangerous goods are involved. The road transport of dangerous goods, regulated according to the international agreement ADR (Accord européen relatif au transport international des marchandises Dangereuses par Route), corresponds to 70% of the Italian transport of dangerous substances. Technologies against distracted and drowsy driving (TAD3) may represent a possible solution to be adopted within this sector. Therefore, the objective of this MS thesis consists in the preliminary analysis of experimental research that compares TAD3 devices through the behavioural response of professional drivers.