The use of nano-sized particles as reinforcing additives for bituminous binders has become, in recent times, increasingly popular, due to the positive effects that nanoparticles induce on a wide range of materials. A considerable literature has grown up around the theme, and the experimental work presented here will contribute to a deeper understanding of nano-additives effects on rheological and morphological properties, with the main purpose of improving the performance of bituminous materials. Much less is known about the connection between rheological parameters and microstructure morphology, therefore this research has thrown up many questions in need of further investigation. In our specific study-case, Nanoclays (Cloisite 15A) and Carbon nanotubes (CNT7000) were added into single base bitumen samples (AZALT 70/100), through several dosages, expressed in percentages by weight, assessed on the base of data derived from previous studies.