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Bench testing for Lyme Disease

Francesco Serra Di Santa Maria

Bench testing for Lyme Disease.

Rel. Candido Pirri. Politecnico di Torino, Corso di laurea magistrale in Nanotechnologies For Icts (Nanotecnologie Per Le Ict), 2018


Lyme disease manifests with two main stages: the earlier is characterized by general symptoms such as headache and fever, plus a typical “bull’s-eye” shaped skin rush (Erythema migrans); the later shows a worsening of those general symptoms from Early Lyme and reaches deeper organs such heart, brain and joints. Although a few weeks of antibiotics are in most cases enough to recover from Early Lyme, if the illness degenerates into its later stage, it may lead to permanent damage to nervous and musculoskeletal systems. Therefore, it results urgent to develop a high-performance diagnostic tool for recognizing Lyme disease even in its early stage, exactly where present golden standards in diagnostics struggle still today, showing a sensitivity of 48% (Early Lyme). In the following work, it was studied how to implement a microfluidics-based version of indirect ELISA testing for Lyme disease and its performances with particular care for diagnosing Early Lyme.

Relators: Candido Pirri
Academic year: 2018/19
Publication type: Electronic
Number of Pages: 34
Additional Information: Tesi secretata. Full text non presente
Corso di laurea: Corso di laurea magistrale in Nanotechnologies For Icts (Nanotecnologie Per Le Ict)
Classe di laurea: New organization > Master science > LM-29 - ELECTRONIC ENGINEERING
Ente in cotutela: Sia Lab, at Columbia School of Engineering, Columbia University, New York (STATI UNITI D'AMERICA)
Aziende collaboratrici: UNSPECIFIED
URI: http://webthesis.biblio.polito.it/id/eprint/9028
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