The present work is focused on the implementation of smart control strategies applied to a Ground-Source Heat Pump system (GSHP), for Space Heating (SH) and Domestic Hot Water (DHW) needs, in a Swedish single-family house. In particular, the developed rule-based control logics, using both a predictive and non-predictive approach, take into account human behaviour and weather information, such as the profiles of the DHW consumption and of the internal heat gains, and the solar radiation data. The study is carried out by means of TRNSYS® numerical simulations. An existing system model (Layout A), developed by Braida and Tomasetig from Polytechnic University of Milan [1], which includes a typical Swedish building, a single-speed GSHP unit, an auxiliary heater and a stratified storage tank, has been adapted to a different system layout (Layout B).