Silicone breast implants are widely used for breast augmentation, reconstruction, or to correct breast deformities. However, silicone is often associated with bacterial infection and biofilm formation. This thesis aims to overcome this limitation by developing a natural polymers-based coating made of chitosan and pectin, crosslinked with genipin and loaded with antibacterial Manuka honey derivative methylglyoxal (MGO). Layer by layer (LbL) self-assembly technique was employed to design an eight-bilayer coating on PDMS substrates previously functionalized with (3-Aminopropyl)triethoxysilane (APTES) through plasma treatment in order to provide superficial charge.Different formulations with varying amounts of MGO were produced and extensively characterized, both crosslinked and non-crosslinked.