Marco Costa
Statistical shape modelling of patient-specific coronary arteries.
Rel. Umberto Morbiducci, Bianca Griffo, Alessandra Aldieri, Maurizio Lodi Rizzini. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Coronary arteries are susceptible to atherosclerosis, a chronic inflammatory condition of the arterial wall that gradually narrows the lumen due to plaque buildup and leading to coronary artery disease (CAD), ranking as the third leading cause of death globally. In this context, arterial anatomical features play a key role in shaping local hemodynamics and its harmful effects on the endothelium, which contribute to the onset and progression of CAD. Statistical shape models (SSMs) are increasingly being used in the cardiovascular field to investigate the complex anatomical variations of cardiovascular structures. By capturing the geometric variability within populations, SSMs might enable the identification of specific shape patterns and deviations associated with diseases.
This work aims to develop two different SSMs to describe the geometric variability of diseased left anterior descending coronary arteries (LAD) without side branches
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