Simone Scalera
Computational insights on the role of metal ions as stabilizers for chaperone-amyloid interactions =.
Rel. Marco Agostino Deriu, Marcello Miceli. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
The most common type of dementia, Alzheimer's disease is characterized by a steadily declining neurological state. There are two primary categories of neuropathological alterations in this illness. The first category consists of positive lesions, which are identified in the brains of the afflicted individuals by the build-up of neurofibrillary tangles, amyloid plaques, dystrophic neurites, neuropil threads, and other aberrant deposits. The existence of senile plaques, and extracellular deposits of beta-amyloid protein (Aβ), is one of the main reasons for these alterations. The accumulation of Aβ plays a major role in neurotoxicity, which has several detrimental impacts on the health of neurons.
Extracellular misfolded Aβ peptide accumulation is thought to start several years before the observable signs and symptoms of Alzheimer's disease
Relatori
Anno Accademico
Tipo di pubblicazione
Numero di pagine
Informazioni aggiuntive
Corso di laurea
Classe di laurea
URI
![]() |
Modifica (riservato agli operatori) |
