In the context of climate change threats, sustainability and climate resilience efforts, this research has the aim to evaluate the feasibility of achieving climate resilience targets within the building sector by 2050. A significant challenge arises from the frequently discrepancy between the performance of buildings during the design phase and the practical results observed in real-use conditions, which are influenced by the changing climate. For this reason, the research approach goes beyond conventional retrofitting strategies, focusing instead on assessing a building's potential to respond to climate change, even in regions historically unaffected by high cooling demands. A mixed-use building (residential and offices) in London serves as a case study, analysing energy behaviour, overheating risks, and carbon emissions within probabilistic scenarios for 2050s and 2080s.