Wearable sensors and flexible electronics are closely intertwined technologies that are revolutionizing various fields, particularly health monitoring, and are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Especially, this thesis focus on Organic Electrochemical Transistors (OECTs), which have recently emerged as a highly promising technology in the area of biosensing and flexible electronics. This thesis work is part of an industrial project commissioned and funded by Umana Medical “Vita” Project and is the result of a partnership between ChiLab-Materials and Microsystems Laboratory (Politecnico di Torino) in Chivasso and the Institute of Materials for Electronics and Magnetism (IMEM) at the National Research Council (CNR) in Parma.