Following the Artemis Accords signed by Italy and the United States in 2020, a new line of mission proposals was born, focused on NASA's prospects for lunar exploration. The goal of the latter is no longer limited to the return of humans to the Moon but aims to the development of technologies and knowledge necessary to enable long-term or permanent human presence on our natural satellite, with an eye to the future and human exploration of Mars. Italy's role, emphasized in the Accords, is to contribute to the development of enabling technologies for lunar surface exploration. In this light, the Lunar Nano Drone (LuNaDrone) mission concept was conceived.