Climate change phenomena, environmental degradation and air pollution impacts represent a concrete threat to the human well-being of the future years, calling for immediate action by governors, who need to develop tailored policies to tackle these problems. In particular, the current paradigms of energy consumption, being one of the main causes of the above-mentioned problems, must be revised. Although efforts are needed at all levels of governance, urban policymakers can provide a significant contribution to the cause. In fact, even if cities only account for less than 2% of the Earth’s surface, they consume 78% of the world’s energy. Dedicated science-based tools can provide an effective support to the decision-making process, helping in the development of appropriate policies.