The need to reduce the environmental impact of the production pipeline of many synthetic biomaterials combined with the requirements of biomedical applications (e.g., cytocompatibility and bioactivity) have directed the latest biomedical research towards the engineering of novel optimised biomaterials. Poly(hydroxy alkanoate)s, PHAs, represent in this regard a green alternative to traditional polymeric materials, because they are produced by bacteria and only require few chemical compounds for their production. Poly(ester urethane)s, PURs, are also interesting candidates due to the possibility to ad-hoc select their building blocks to satisfy specific requirements for tissue engineering (TE) applications. In this scenario, this thesis project focused on the synthesis and chemical modification of a medium chain length PHA (mcl-PHA), which synthesis was carried out at The University of Sheffield (UK) (Prof.