Marta Saporito
Implementation of a control system for SAR and temperature focusing in a head and neck cancer hyperthermia applicator.
Rel. Giuseppe Vecchi, Rossella Gaffoglio, Giorgio Giordanengo, Marcello Zucchi, Giuseppe Musacchio Adorisio. Politecnico di Torino, Master of science program in Electronic Engineering, 2022
Abstract
Hyperthermia therapy is exploited in the medicine field combined with the most known cancer treatments - radiotherapy and chemotherapy - to improve their effectiveness. During hyperthermia treatments, the tumor tissues are heated up to 42/43°C through non-ionizing microwave radiation generated by proper antenna applicators. Overheating makes the cells more sensitive to ionizing radiations and enhances drug delivery without adding further toxicity. These benefits have been demonstrated for tumor sites like cervix, breast, head and neck, skin, bladder, and esophagus. For the treatment of internal tumors, properly phased antenna arrays are currently used in the clinical practice to maximize the specific absorption rate (SAR) (and hence the temperature increase) in the tumor target, while avoiding formation of hotspots in the surrounding healthy tissues.
This is achieved by means of proper optimization routines based on numerical simulations and an active electronic control system able to provide the optimized antenna feedings to the antennas of the array during the whole heating session
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