This study investigates a molecularly imprinted electrochemical sensor for sensitive dopamine (DA) determination. The purpose of this work is to develop high- performance and miniaturizable sensors for DA, a neurotransmitter (NT) involved in many neurological diseases. The concentration of NTs in the human body is extremely low and, for this reason, the sensor utilized for their detection should have physiologically relevant sensitivity. Molecular imprinting consists in the formation of a polymeric layer modified with recognition sites to a particular target analyte. This is carried out through the polymerization of the functional monomer in the presence of the target. The electrodes developed in this study are based on a silicon substrate, modified with a tetraheadral amorphous carbon (ta-C) layer and a DA imprinted polypyrrole (PPy) layer.