Heart diseases are the leading cause of death globally. Among them, the most common one is the myocardial infarction that occurs when in the coronary artery of the heart the blood flow decreases or stops. The heart cells, particularly cardiomyocytes, are very sensitive to oxygen deficiency and suddenly die. To minimize damages as quickly as possible, a wound-healing process begins, which includes: the proliferation and maturation of cardiac fibroblasts into myofibroblasts, the deposition of new extracellular matrix (ECM), and an increase in the content of type I and III collagen. All of these processes result in myocardial fibrosis and stiffness of heart tissue.