In this work we investigate the potential of microwave sensors for the early detection of Lymph Oedema (LO) which could contribute in avoiding complications and reducing costs for the healthcare system. LO is a chronic disease characterized by the over-accumulation of lymphatic fluids in the body, which generally causes the swelling located in one arm or leg, sometimes both arms and/or legs. Although many medical solutions have been explored targeting the possibility of preventing and detecting the illness, especially considering high-risk factors and implying additional expansive tests, like Magnetic Resonance Imaging (MRI) or Computerized Tomography (CT) Scan, the idea of using microwave sensors can represent a valid, efficient and cost-effective alternative.